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. 2021 Sep 10;7(37):eabg7291. doi: 10.1126/sciadv.abg7291

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Fig. 1. — (A) Chemical structures and responsive switch on of redox- and acidic pH–responsive Sw-IMs. Sw_redoxIM, redox-responsive Sw-IM; Sw_pH(D/S)IM, acidic pH–responsive Sw-IM with dibenzocyclooctyne (DBCO) or thioether spacer. (B) Schematic illustration of the preparation and in vivo fate of Sw-IMs. Sw-IMs remain switched off in the circulation and healthy tissues and get switched on specifically in the TME to stimulate proliferation and effector functions of CD8⁺ T cells and NK cells for cancer immunotherapy. (C) Modular design of Sw-IMs by tuning the conjugation ratio (R_C) and MW (M_PEG) of masking polymers. R_C is defined as the percentage of conjugated amino groups among all the detectable amino groups of an IM.