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. 2021 Sep 10;7(37):eabg7996. doi: 10.1126/sciadv.abg7996

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3. — (A) Heatmap showing the individual lung histopathology scores for each ferret and parameter following FIV or Ad-GFP vaccination and challenged with SARS-CoV-2 and culled at 6/7 days and 13/15 days after challenge. Histopathology of FIV-vaccinated (B to E) and Ad-GFP–vaccinated (F to I) ferrets. (B) Inflammatory infiltrates within a bronchiole (*), with abundant mononuclear cells but also some neutrophils and eosinophils. Hematoxylin and eosin (H&E), 200×. (C) Multiple inflammatory infiltrates surrounding blood vessels (perivascular cuffing, arrows). H&E, 100×. The infiltrates are composed mostly of macrophages and lymphocytes, but abundant eosinophils can also be observed in some areas within the infiltrates (inset; H&E, 400×). (D) Perivascular cuff (arrow) with abundant mononuclear cells, many of them identified as CD3⁺ T lymphocytes. Immunohistochemistry, 200×. (E) Periportal mononuclear inflammatory infiltrate in the liver (mild multifocal hepatitis). H&E, 400×. (F) Mild inflammatory infiltrate within a bronchiole (*). H&E, 200×. (G) Blood vessel (arrow) within the lung parenchyma not showing any perivascular cuffing. H&E, 200×. (H) In situ hybridization (ISH) detection of SARS-CoV-2 RNA in a small focus of epithelial and sustentacular cells within the nasal cavity. ISH, 200×. (I) Periportal mononuclear inflammatory infiltrate in the liver (mild multifocal hepatitis). H&E, 400×.