Table 1. Experimental animal groups.
Group | Number of animals |
Vaccination—days before
challenge |
Sampling |
Euthanasia days after
challenge |
Ferret – Ad-GFP | 4 females | 28 | Blood for serology before vaccination, on day of challenge, and at necropsy. |
6 days; n = 2 |
13 days; n = 1 | ||||
14 days; n = 1 | ||||
Ferret – FIV | 6 females | 14 | Nasal washes and throat swabs on days 0, 2, 4, 6, 8, 10, and 12 after challenge and necropsy |
7 days; n = 2 |
14 days; n = 4 | ||||
Rhesus macaque – no vaccine | 3 males | 14 | Blood serology before vaccination, on day of challenge and day 7 after challenge. |
7 days; n = 6 |
3 females | ||||
Rhesus macaque – FIV | 3 males | – | Nasal wash and throat swab on days 1, 3, 5, and 7 after challenge. BAL at necropsy. |
7 days; n = 6 |
3 females |