Fig. 9. Exercise mitigates tumor-associated anemia.

Graphical illustration of tumor-induced inflammatory and metabolic remodeling that affects RBC survival by activating splenic phagocytes and increasing the susceptibility of RBCs to be eliminated, which eventually results in anemia and increased fatiguability. Exercise can partially normalize this tumor-induced remodeling and thereby ameliorate the development of anemia and substantially elevate performance. This figure was created with BioRender.com.