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. 2021 Sep 1;7(36):eabg8764. doi: 10.1126/sciadv.abg8764

Fig. 3. Stat1−/− naïve CD8+ T cells proliferate in response to T1IFN and IL-7 in vitro and in vivo.

Fig. 3.

(A) In vitro proliferation of WT and Stat1−/− naïve CD8+ T cells in culture with indicated cytokines. (B) Percentage of proliferating WT and Stat1−/− naïve CD8+ T cells in culture with IL-7 and IFN-β. (C) Experimental scheme for (D) and (E). i.p., intraperitoneally. (D) In vivo proliferation and (E) CD44 expression levels of WT and Stat1−/− CD8+ donor cells from B6 recipients. (F) Experimental scheme for (G). (G) In vivo proliferation of WT and Stat1−/− CD8+ donor cells from irradiated (500 cGy) B6 recipients. (H) Experimental scheme of in vivo T1IFN blockade for (I). (I) In vivo proliferation of WT and Stat1−/− CD8+ donor cells from untreated or αIFNAR-treated irradiated B6 recipients. The results are presented as means ± SEM. Data are representative of three to four independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001. n.s., not significant.