Fig. 5. Stat1−/− naïve CD8+ T cells induce severe forms of colonic inflammation in an IBD setting.
Size (A) and weight (B) of the spleens of 20-week-old WT, Stat1−/−, and Stat1−/−.Ifnar−/− mice. (C and D) Absolute cell number of total splenocytes and splenic CD44hi CD8+ T cells from mice in (B). (E) Experimental scheme of inducing IBD for (F) and (G). (F) Representative histochemistry [left hematoxylin and eosin (H&E) staining] and histopathological score (right bar graph) of the distal colon sections of Rag1−/− recipient mice. (G) Representative histochemistry (left) and histopathological score (right) of the liver sections of Rag1−/− recipient mice. The results are presented as means ± SD. Data are representative of three to four independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.