Figure 1:

Importance of reduced bias in the template choice. In the zoomed-in region, a biased template (e.g., a template that does not represent the subject well) can be more likely to expand (distort) the original area than a well-picked (or study specific) template. The sulcus in the zoomed-in region becomes wider with the biased template because the cohort used in this template has different gyral patterns from those of the input, which results in the expansion of the sulcal region of the input. Depending on the template choice, the secondary level data analysis can be affected by distorted surface areas.