. Author manuscript; available in PMC: 2022 Mar 30.

Published in final edited form as: J Am Coll Cardiol. 2021 Mar 30;77(12):1503–1516. doi: 10.1016/j.jacc.2021.01.050

Table 4:

Proportion of patients meeting the various components of the modified Lake Louise Criteria in all included patients and those with biopsy proven ICI myocarditis. Abnormal T1 and T2 values were defined as mean + 2SD above site, CMR vendor and field strength specific reference ranges.

	All cases N (%)	Biopsy proven cases N (%)
Main Criteria	Total N =79^*	Total N=31^*
• Non-Ischemic Myocardial Injury (Abnormal T1, ECV^†, or LGE)	75 (95%)	28 (100%)
• Myocardial Edema (T2-mapping or T2W images)	42 (53%)	19 (63%)
Supportive Criteria
• Pericarditis	14 (18%)	8 (26%)
• Systolic LV dysfunction (<55%)	33 (42%)	16 (52%)
Combinations
• Patients with both main criteria	38 (48%)	16 (52%)
• Patients with either main criteria	79 (100%)	31 (100%)
• Patients without T1 or T2 elevation or supportive criteria	0 (0%)	0 (0%)

These numbers refer to patients who had both T1 and T2 maps.

^†

ECV was only available in 19 patients in the entire cohort of 79 patients, and 10 patients amongst those with biopsy proven disease. ECV=extracellular volume fraction; LGE=late gadolinium enhancement; T2W = T2 weighted images; LV=left ventricular