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. 2021 Sep 1;12:672252. doi: 10.3389/fphys.2021.672252

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Copyright © 2021 Parker, Tate, Prakoso, Deo, Willis, Nash, Donner, Crawford, Kiriazis, Granata, Coughlan, De Blasio and Ritchie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LV mitochondria function in diabetic mice. (A) Representative mitochondrial oxygen consumption trace in diabetic mice (red line) and non-diabetic mice (blue line). Image has been cropped where lines are broken. Cytochrome C addition not shown. Oroboros high-resolution respirometry analysis of: (B) Complex-I^LEAK respiration, (C) Complex-I oxygen consumption, (D) Complex-II oxygen consumption. LV gene expression of (E) mitochondrial uncoupling protein-3 (UCP3). Data represented as mean ± SEM. n = 9–14 per group (note individual data points). Data analysis was carried out using unpaired t-test. *P < 0.05, ***P < 0.001. ND, non-diabetic; D, diabetes; LV, left ventricle.