Table 2.

ORR and DRR per TC PD-L1 (≥1%) and log density of CD8⁺PD-1⁺TIM-3⁻LAG-3⁻ TIC levels (High vs Low) in the nivo arm.

Marker Combination	Nivo (n = 111)a
	n	ORR% (n)	DRR% (n)
PD-L1 High / CD8+ PD1+TIM3−LAG3− TIC High	12	50% (6)	33% (4)
PD-L1 Low / CD8+ PD1+TIM3−LAG3− TIC High	90	22% (20)	18% (16)
PD-L1 Low / CD8+ PD1+TIM3−LAG3− TIC Low	9	11% (1)	0% (0)
Trend test 1-sided p-value		0.027	0.045

^aAssociation of the biomarkers with ORR and DRR was not assessed in the evero arm due to the low number of responders.