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. 2021 Sep 15;16(9):e0255170. doi: 10.1371/journal.pone.0255170

Table 2. Outcomes of CABG stratified by sex and multivariable regression analysis showing odds of developing post-operative complications following CABG in female patients with males as reference.

Variable Female (%) Male (%) p-value Unadjusted analysis Adjusted analysisa
OR p-value OR p-valueb
Stroke 46 (3.2) 54 (1.1) <0.001
Sepsis 10 (0.7) 24 (0.5) 0.288
DSMI 14 (1.0) 12 (0.2) <0.001
Ventilator dependence >48 hours 200 (13.9) 398 (7.8) <0.001 1.92 (1.60, 2.30) <0.001 1.65 (1.21, 2.45) 0.002
Pneumonia 26 (1.8) 97 (1.9) 0.837
Renal Failure 49 (3.4) 81 (1.6) <0.001 2.20 (1.53, 3.15) <0.001 0.99 (0.63, 1.54) 0.946
Heart Block 21 (1.5) 26 (0.5) <0.001
Cardiac Arrest 26 (1.8) 55 (1.1) 0.026
GI complications 29 (2.0) 88 (1.7) 0.446 1.18 (0.77, 1.80) 0.447 0.94 (0.59, 1.49) 0.788
Atrial Fibrillation 338 (23.6) 1269 (24.8) 0.333 0.93 (0.81, 1.07) 0.333 1.10 (0.96, 1.26) 0.202
Reoperation for cardiac complication 17 (1.2) 32 (0.6) 0.030
Reoperation for non-cardiac complication 66 (4.9) 191 (3.9) 0.094 1.37 (0.95, 1.98) 0.095 1.24 (0.23, 1.86) 0.293
Cardiac readmission 140 (9.8) 282 (5.5) <0.001 1.85 (1.50, 2.29) <0.001 1.56 (1.27, 2.30) 0.003
Non-cardiac readmission 161 (11.2) 324 (6.3) <0.001 1.87 (1.53, 2.28) <0.001 1.16 (0.77, 2.40) 0.402
Duration of stay (days) c 7.19 ± 5.93 6.30 ± 4.64 <0.001 0.074 (0.148) <0.001 -0.108 (0.182) 0.554
30 day Mortality 46 (3.2) 75 (1.5) <0.001 2.23 (1.54, 3.23) <0.001 1.55 (1.01, 2.40) 0.046

aAdjusted for, obesity, smoking status, diabetes, hypertension, history of myocardial infarction, heart failure, pre-operative ejection fraction and IABP use, heparin and anti-platelets, number of diseased vessels, IMA utilization, number of arterial and venous grafts and year of surgery.

bBonferroni correction applied for multivariable regression—p<0.0045 considered significant.

cResults of Linear regression analysis reported as standardized coefficient (coefficient standardized error)

DSMI: Deep sternal mediastinal infection; GI: gastrointestinal; IMA: Internal mammary artery.