Table 2. Summary statistics for the eligible UK biobank cohort.

	Unaffected Total 401,006	Affected (incident cases) Total 2,992
	N (%)	N (%)
Age at cohort entry (years)
40–49	88,648 (22.11)	198 (6.62)
50–59	133,056 (33.18)	800 (26.74)
60–69	179,302 (44.71)	1,994 (66.64)
Age when diagnosed with colorectal cancer (years)
40–49	–	79 (2.64)
50–59	–	496 (16.58)
60–69	–	1,647 (55.05)
70–79	–	770 (25.74)
Gender
Female	217,501 (54.24)	1,275 (42.61)
Male	183,505 (45.76)	1,717 (57.39)
Number of first-degree relatives diagnosed with colorectal cancer
0	356,437 (88.89)	2,544 (85.03)
1	42,129 (10.51)	412 (13.77)
2+	2440 (0.61)	36 (1.20)
	Mean (SD) median	Mean (SD) median
Full lifetime risk: combined model	0.068 (0.041) 0.057	0.080 (0.050) 0.067
10-year risk: combined model	0.011 (0.009) 0.008	0.016 (0.013) 0.013
Relative risk: PRS	0.999 (0.574) 0.848	1.112 (0.657) 0.934