Table 1.
Clinical characteristics of the recipients and the donors
| Characteristics | Group 1 (n=150) n (%) | Group 2 (n=1000) n (%) | P |
|---|---|---|---|
| Age, years ± (SD) | 69±7.5 | 41±8 | 0.02 |
| Male gender, n (%) | 120 (80) | 820 (82) | - |
| ESRD cause, n (%) | |||
| Diabetes mellitus | 79 (52.3) | 414 (41.4) | NS |
| Chronic Glomerulonephritis | 30 (20.33) | 300 (30) | - |
| Chronic interstitial nephritis | 22 (14.7) | 228 (22.8) | - |
| Hypertensive nephrosclerosis | 12 (8.33%) | 10 (1) | <0.05 |
| Undetermined | 7 (4.37) | 48 (4.8) | - |
| Co-morbidities | |||
| Diabetes | 82 (55) | 452 (45.2) | NS |
| Hypertension | 127 (85) | 900 (90) | - |
| Coronary artery disease | 46 (31) | 250 (25) | - |
| Peripheral artery disease | 9 (6) | 30 (3) | - |
| Chronic obstructive pulmonary disease | 12 (8) | 40 (4) | - |
| ABO-incompatible | 25 (17) | 250 (25) | NS |
| Pre-emptive Transplant | 20 (13.5) | 160 (16) | - |
| Median time in dialysis, months | 12 (2-36) | 8 (1-30) | NS |
| Hemodialysis | 115 (88) | 750 (89.2) | - |
| Peritoneal dialysis | 15 (12) | 90 (10.7) | - |
| HLA Mismatch | |||
| 1 | 25 (16.7) | 208 (20.8) | - |
| 2 | 23 (15.7) | 170 (17) | - |
| 3 | 31 (20.7) | 180 (18) | - |
| 4 | 21 (14.7) | 140 (14) | - |
| 5 | 32 (22.0) | 172 (17.2) | - |
| 6 | 19 (13.3) | 130 (13) | - |
| Donor characteristics | |||
| Age | |||
| < 50 years | 57 (38) | 790 (79) | <0.05 |
| 50-60 years | 69 (45.8) | 200 (20) | 0.02 |
| 60-70 years | 24 (16.2) | 10 (1) | 0.004 |
| Living donors (%) | 150 (100) | 1000 (100) | - |
| Relationship with recipient, n (%) | |||
| Siblings | 56 (37.5) | 144 (14.4) | <0.05 |
| Spouse | 54 (35.5) | 390 (39) | NS |
| Children | 3 (2) | 3 (0.3) | - |
| Other relatives | 37 (25) | 131 (13.1) | - |
| Parents | - | 332 (33.2) | 0.002 |
| Induction agent | 123 (82) | 840 (84) | - |
| Basiliximab | 34 (27.8) | 200 (23.8) | - |
| Anti- thymocyte globulin | 89 (72.2) | 640 (76.2) | - |
| Initial immunosuppression | |||
| Steroid +Mycophenolate Mofetil + tacrolimus | 142 (95.2) | 978 (97.8) | NS |
| Steroid + Mycophenolate Mofetil + Cyclosporine | 6 (3.4) | 12 (1.2) | NS |
| Steroid + Azathioprine + Tacrolimus | 2 (1.4) | 10 (1) | NS |