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K334 is critical for TRIM8-mediated degradation
(A) Schematic of lysine mutants of EWS/FLI. Lysine positions correspond to the positions found in WT EWS and FLI1 proteins.
(B and C) Indicated EWS/FLI lysine mutants were co-transfected with either TRIM8 or a vector control in 293T cells. After 48 h, cells were lysed and immunoblotted with the indicated antibodies. Data representative of three independent experiments.
