Table 2.

HPA Axis Functioning and Frontolimbic Connectivity

	Healthy control	MDD	Comparisons
TSST Start Time
M (SD)	15:01(1:11)	14:45 (1:13)	t(86) = .99, p = .32
Range	12:51 – 16:14	13:00 – 16:28
TSST AUCg
M (SD)	18.09 (11.65)	20.29 (12.68)	t(86) = .82, p = .42
Range	1.74 – 42.38	2.30 – 53.48
TSST AUCi
M (SD)	3.16 (9.70)	.92 (13.45)	t(86) = .83, p = .41
Range	−26.83 – 20.19	−32.23 – 40.36
TSST Highest
M (SD)	.42 (.25)	.44 (.25)	t(86) = .40, p = .69
Range	.03 – 1.00	.04 – .94
L Amygdala-vmPFC RSFC
M (SD)	.30 (.80)	.39 (.78)	t(86) = .51, p = .61
Range	−1.23 – 3.04	−1.34 – 2.23
R Amygdala-vmPFC RSFC
M (SD)	.42 (.74)	.33 (.90)	t(86) = .45, p = .65
Range	−1.23 – 2.26	−1.66 – 2.95
L Amygdala-dmPFC RSFC
M (SD)	.09 (.50)	.07 (.50)	t(86) = .24, p = .81
Range	−1.07 – .92	−.94 – 1.03
R Amygdala-dmPFC RSFC
M (SD)	.06 (.59)	.04 (.50)	t(86) = .13, p = .90
Range	−1.32 – 1.23	−1.18 – 1.10

Note. MDD = major depressive disorder, TSST = Trier Social Stress Test; AUCg = area under the curve with respect to ground; AUCi = area under the curve with respect to increase; vmPFC = ventral medial prefrontal cortex; dmPFC = dorsal medial prefrontal cortex; RSFC = resting state functional connectivity (values indicate z values)