Table 2.

Summary of extracted data

Author	Study type (POS, ROS, RCT)	Number of pt	Age (ye ars)	Gender		Mean radiation dosag e (gray)	HBO	Impl location (number of impl)		Impl placed	Mean time interval		Impl in sit u	Impl lost	ORN cas es	Mean follow-up (months)
				Male	Female			max vs. mand	Native vs. graft		RT and impl (months)	Impl and loading (months)
Brogniez et al. 1998 [88]	ROS	19	53	16	3	57 (1 pt Ø)	0	max: 3, mand: 50	Mixed	53	17, post-RT	6	36	17	0	38
Keller et al. 1998 [89]	ROS	31 (total)	50.5	16	15	Ø	0	mand	Mixed	154	Ø	Ø	147	7	0	64.2
		19	41.5	12	7	0	0	mand	Native: 19 Graft: 72	91	Ø	7.8	85	6	0	77.5
		3	41.3	1	2	0	0	mand	Native: 7 Graft: 9	16	Ø	5–6	16	0	0	28.7
		4	65.5	0	4	62.1	0	mand	Native: 12 Graft: 10	22	> 7, post-RT	4–6	22	0	0	50
		5	57	3	2	60.8	0	mand	Native: 7 Graft: 18	25	> 13, post-RT	4–6	24	1	0	42.2
Esser et al. 1999 [90]	ROS	28	55.3	23	5	0	0	mand	Native	128	Ø	5.1	106	22	0	53.3
		34	54.7	28	6	60	0	mand	Native	148	23.1, post-RT	5.2	73	75	1	62.2
Schoen et al. 2003 [91]	ROS	5	54	3	2	61.6	Ø	mand	Ø	20	1.5, pre-RT	6	16	4	0	22
Iizuka et al. 2005 [76]	ROS	28 (total)	58.2	19	9	65: 19 pt 0: 9 pt	0	mand	Ø	37	Ø	Ø	37	0	0	45
		18	Ø	Ø		65: 9 pt 0: 9 pt	0	mand	Ø	24	Post-RT: 9 pt	Ø	24	0	0	Ø
		10	Ø	Ø		65	0	mand	Ø	13	Pre-RT: 7 pt Pre + post-RT: 3 pt	Ø	13	0	0	Ø
Shaw et al. 2005 [92]	ROS	77 (total, 4 dropouts excluded)	58	49	32	Ø	24	Mixed	Native: 241 Graft: 123	364	Ø	3–6	308	56	2	42
		43	Ø	Ø		Ø	7	Mixed	Ø	192	Ø	3–6	167	25	0	Ø
		34	Ø	Ø		50 (3 pt Ø)	17	Mixed	Ø	172	12, post-RT	3–6	141	31	2	Ø

HBO, hyperbaric oxygen therapy; impl, implants; mand., mandible; max, maxilla; ORN, osteoradionecrosis; POS, prospective observational study; pt, patients; RCT, randomized control study; ROS, retrospective observational study; RT, radiotherapy; Ø, unspecified