Table 4.

Observed changes in outcomes in included studies

Study	Outcomes measured at	Mean reduction in PPD ± SD (mm)	Mean gain in CAL ± SD (mm)	Key findings
Gandhi et al. 2019 [34]	3 months	NSPT + ICG-PDT = 2.79 ± 0.63 NSPT = 1.19 ± 0.82	NSPT + ICG-PDT = 2.69 ± 0.68 NSPT = 1.16 ± 1.09	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
	6 months	NSPT + ICG-PDT = 1.74 ± 1.11 NSPT = 0.75 ± 0.90	NSPT + ICG-PDT = 1.63 ± 1.43 NSPT = 0.74 ± 1.19	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Joshi et al. 2020 [35]	3 months	NSPT + ICG-PDT = 2.36 ± 0.37 NSPT = 2.10 ± 0.35	NSPT + ICG-PDT = 2.34 ± 0.37 NSPT =2.10 ± 0.35	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Monzavi et al. 2016 [36]	3 months	NSPT + ICG-PDT = 2.54 ± 0.29 NSPT = 0.63 ± 0.79	NSPT + ICG-PDT = 1.36 ± 0.77 NSPT = 1.55 ± 0.76	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Raut et al. 2018 [37]	6 months	NSPT + ICG-PDT = 2.51 ± 0.40 NSPT = 1.00 ± 0.62	NSPT + ICG-PDT = 1.68 ± 0.82 NSPT = 0.72 ± 0.75	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Sethi et al. 2019 [38]	3 months	NSPT + ICG-PDT = 1.86 ± 1.11 NSPT = 0.70 ± 0.60	NSPT + ICG-PDT = 1.41 ± 1.20 NSPT = 0.99 ± 0.77	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Shingnapurkar et al. 2016 [39]	3 months	NSPT + ICG-PDT = 2.90 ± 0.75 NSPT = 1.60 ± 0.78	NSPT + ICG-PDT = 2.53 ± 0.75 NSPT = 1.23 ± 1.22	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
Srikanth et al. 2015 [40]	3 months	NSPT + ICG-PDT = 2.91 ± 0.73 NSPT = 2.07 ± 0.27	NSPT + ICG-PDT = 2.44 ± 0.80 NSPT = 1.50 ± 0.49	NSPT with ICG-PDT was significantly more efficacious than NSPT alone
	6 months	NSPT + ICG-PDT = 2.74 ± 0.52 NSPT = 2.06 ± 0.17	NSPT + ICG-PDT = 2.47 ± 0.40 NSPT = 1.40 ± 0.49	NSPT with ICG-PDT was significantly more efficacious than NSPT alone