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. 2021 Sep 15;11:18330. doi: 10.1038/s41598-021-97406-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of patch clamp experiments. We compared the mean current densities @ + 60 mV of erlotinib-sensitive WT A549-3R and erlotinib-resistant A549-3R cells. The contribution of K_Ca3.1 and K_Ca1.1 channels to the outward current induced by the application of 1-EBIO (50 µmol/L) is disclosed by adding the K_Ca1.1 blocker paxilline (pax; 10 µmol/l) or the K_Ca3.1 blocker senicapoc (sen; 1 µmol/L). A549-3R WT: N = 9, erlotinib-resistant cells: N = 10. * indicates p < 0.05.