Table 3.

The most correlative EST features with Uaa mutant soluble fraction.

Top features	EST	R Value	Description
1	np_bb_sc_intra	0.503	Intra-residue backbone to sidechain nonpolar contacts
2	total_np_contacts	0.488	Total number of nonpolar contacts
3	np_sc_sc_inter	0.390	Inter-residue sidechain to sidechain nonpolar contacts
4	total_contacts	0.376	Total number of polar and nonpolar contacts
5	p_sc_sc_inter	0.321	Inter-residue sidechain to sidechain polar contacts
6	ASA	0.241	Accessible surface area
7	kD_cyclohexane_water	0.226	Measure of hydrophobicity
8	RSA	0.223	Relative accessible surface area
9	kD_vapor_to_water	0.219	Measure of hydrophobicity
10	kD_octanol_to_water	0.215	Measure of hydrophobicity

Definitions of features can be found in Supplementary Table 3.