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Melatonin alleviates renal dysfunction in sepsis-induced acute kidney injury. 8-week-old mice were treated with melatonin (25 μg/ml) dissolved in drinking water for 14 days. Effects of MLT on the concentration of serum (A) BUN and (B) SCR (* vs. sham, p < 0.05; # vs. CLP, p < 0.05). (C) Representative images of HE staining and Masson trichrome staining of kidney tissues (scale bar = 50 µm). (D) Percentage of renal injury was quantified (* vs. sham, p < 0.05; # vs. CLP, p < 0.05).
