TABLE 1.
Characteristics | No ARDS (n = 731) | ARDS (n = 262) | Overall (n = 993) | p |
---|---|---|---|---|
Age, yr, median (IQR) | 56 (45–67) | 56 (47–65) | 56 (47–56) | 0.868 |
Male sex, n (%) | 394 (54) | 135 (52) | 529 (53) | 0.517 |
Albumin, g/dL, median (IQR) | 2.7 (2.3–3.2) | 2.5 (2.2–3.0) | 2.8 (2.3–3.1) | < 0.001 |
ICU location, n (%) | ||||
Surgical | 79 (11) | 33 (13) | 112 (11) | 0.053 |
Medical | 622 (85) | 226 (86) | 848 (85) | |
Cardiovascular | 30 (4) | 3 (1) | 33 (3) | |
Risk factors for ARDS at enrollment, n (%) | ||||
Nonpulmonary sepsis | 283 (39) | 108 (41) | 391 (39) | < 0.001 |
Pneumonia | 98 (13) | 78 (30) | 176 (18) | |
Multiple transfusions | 93 (13) | 11 (4) | 104 (10) | |
Aspiration | 44 (6) | 48 (18) | 92 (9) | |
Pancreatitis | 20 (3) | 2 (1) | 22 (2) | |
Drug overdose | 32 (4) | 1 (0) | 33 (3) | |
Other | 8 (1) | 11 (4) | 19 (2) | |
None | 116 (16) | 2 (1) | 118 (12) | |
Not available/missing | 37 (5) | 1 (0) | 38 (4) | |
Acute Physiology and Chronic Health Evaluation Score II score, median (IQR) | 26 (21–32) | 30 (25–36) | 27 (22–33) | < 0.001 |
72-hr cumulative fluid balance liters, median (IQR) | +3.0 (0.0–6.1) | +4.1 (1.2–7.7) | +3.2 (0.5–6.6) | 0.001 |
Inhospital AKI by Kidney Disease Improving Global Outcomes stage, n (%) | ||||
No AKI (stage 0) | 138 (19) | 24 (9) | 162 (16) | < 0.001 |
AKI present (stages 1–3) | 584 (80) | 235 (89) | 819 (82) | |
Insufficient data | 9 (1) | 3 (1) | 12 (1) | |
Baseline estimated glomerular filtration rate, mL/min/1.73 m2, median (IQR) | 75 (45–103) | 82 (55–108) | 77 (48–105) | 0.013 |
Inhospital death, n (%) | 163 (22) | 107 (42) | 270 (27) | < 0.001 |
Days in ICU, median (IQR) | 5 (3–9) | 8 (5–13) | 5 (3–10) | < 0.001 |
Days on ventilator, median (IQR) | 2 (0–5) | 5 (3–9) | 3 (0–6) | < 0.001 |
Ventilator-free days, median (IQR) | 25 (11–28) | 13 (0–23) | 23 (5–27) | < 0.001 |
AKI = acute kidney injury, ARDS = acute respiratory distress syndrome, IQR = interquartile range.
p values compare ARDS with non-ARDS group with Fisher exact test for categorical variables and Mann-Whitney U test for continuous variables. Bold font indicates significant p values (p < 0.05).