Table E3.
Complete case analysis of switching to an angiotensin-II receptor blocker after angiotensin converting enzyme inhibitor therapy in people with active asthma compared with the general population and other risk factors
| Characteristic | Crude hazard ratio (95% confidence interval) | Crude P | Adjusted hazard ratio (95% confidence interval) | Adjusted P |
|---|---|---|---|---|
| Population | ||||
| General population | 1.00 | 1.00 | ||
| Active asthma | 1.22 (1.19-1.25) | <.001 | 1.16 (1.13-1.20) | <.001 |
| Chronic obstructive pulmonary disease | 0.83 (0.80-0.86) | <.001 | 0.93 (0.89-0.98) | .002 |
| Hypertension | 1.30 (1.28-1.32) | <.001 | 1.14 (1.12–1.16) | <.001 |
| Cardiovascular disease | 0.83 (0.82-0.85) | <.001 | 0.92 (0.90-0.94) | <.001 |
| Sex | ||||
| Male | 1.00 | 1.00 | ||
| Female | 1.56 (1.54-1.58) | <.001 | 1.52 (1.50-1.55) | <.001 |
| Age at baseline, y | ||||
| <40 | 1.00 | 1.00 | ||
| 40-49 | 1.33 (1.27-1.39) | <.001 | 1.32 (1.24-1.40) | <.001 |
| 50-59 | 1.53 (1.47-1.60) | <.001 | 1.55 (1.46-1.64) | <.001 |
| >60 | 1.72 (1.65-1.79) | <.001 | 1.73 (1.64-1.83) | <.001 |
| Body mass index category | ||||
| <20 | 1.00 | 1.00 | ||
| 20-24 | 1.33 (1.27-1.39) | <.001 | 1.37 (1.29-1.45) | <.001 |
| ≥25 | 1.43 (1.37-1.50) | <.001 | 1.54 (1.45-1.63) | <.001 |
| Smoking status | ||||
| Nonsmoker | 1.00 | 1.00 | ||
| Ex-smoker | 0.90 (0.89-0.92) | <.001 | 0.98 (0.96–0.999) | .045 |
| Current smoker | 0.61 (0.60-0.63) | <.001 | 0.70 (0.68–0.72) | <.001 |
| Deprivation | ||||
| 1 (least deprived) | 1.00 | 1.00 | ||
| 2 | 1.09 (1.07-1.12) | <.001 | 1.07 (1.04-1.10) | <.001 |
| 3 | 1.11 (1.09-1.15) | <.001 | 1.07 (1.04-1.10) | <.001 |
| 4 | 1.17 (1.15-1.17) | <.001 | 1.10 (1.07-1.13) | <.001 |
| 5 (most deprived) | 1.24 (1.21-1.27) | <.001 | 1.20 (1.16-1.23) | <.001 |