Table 4.
The pharmacokinetics, water solubility, and toxicity prediction in 6 potential natural products.
| Compound | Pharmacokinetics |
Water solubility |
Toxicity prediction |
||||
|---|---|---|---|---|---|---|---|
| Human intestinal absorption | logS | Solubility category | Human either-a-go-go inhibition | Ames mutagenesis | Acute oral toxicity (c) | Carcinogenicity (trinary) | |
| Dioscin | – | −4.1278 | Moderate | + | – | III | Non-required |
| Celastrol | + | −3.8627 | low | + | – | III | Non-required |
| Saikosaponin C | + | −3.7177 | High | + | – | I | Non-required |
| Epimedin C | + | −3.4068 | High | + | – | III | Non-required |
| Torvoside K | – | −3.9448 | High | + | – | I | Non-required |
| Amentoflavone | + | −3.3648 | Low | – | – | II | Non-required |