Table 1.

Patient demographics according to the MOLES score and expert diagnosis of choroidal lesions

Clinical findings/categories	MOLES category								Total
	common nevus		low-risk nevus		high-risk nevus		probable melanoma
	n	%	n	%	n	%	n	%	n	%
Sex
Male	49	69	24	67	17	61	47	54	137	62
Female	22	31	12	33	11	39	40	46	85	38
Eye
Left	35	49	18	50	11	39	39	45	103	46
Right	36	51	18	50	17	61	48	55	119	54
Visual acuity
20/20 to 20/30	59	83	31	86	25	93	64	74	179	81
20/40 to 20/60	11	15	4	11	2	7	16	18	33	15
20/80 to 20/200	1	1	1	3	0	0	2	2	4	2
CF	0	0	0	0	0	0	3	3	3	1
HM-NLP	0	0	0	0	0	0	2	2	2	1
MOLES score
Mushroom shape
0: Absent	71	100	36	100	28	100	86	99	222	100
1: Incipient (i.e., erosion of RPE over tumor, possibly with bulging of tumor)	0	0	0	0	0	0	1	1	0	0
2: Present (i.e., with definite overhang)	0	0	0	0	0	0	0	0	0	0
Orange pigment
0: Absent	71	100	35	97	27	96	24	28	158	71
1: Trace	0	0	1	3	1	4	24	28	27	12
2: Confluent (i.e., forming clumps)	0	0	0	0	0	0	39	45	37	17
Large size
0: Small (i.e., base <3 DD and thickness <1 mm)1	71	100	3	8	1	4	1	1	76	34
1: Borderline (i.e., base 3–4 DD or thickness = 1–2 mm)1	0	0	33	92	10	36	29	33	72	32
2: Large (i.e., base >4 DD or thickness >2 mm)1	0	0	0	0	17	61	57	66	74	33
Enlargement
0: None	71	100	36	100	28	100	74	85	209	94
1: Uncertain	0	0	0	0	0	0	0	0	0	0
2: Definite (i.e., with photographic proof of growth >1/3 DD per year)	0	0	0	0	0	0	13	15	13	6
SRF
0: Absent	71	100	34	94	18	64	2	2	125	56
1: Trace (i.e., detected only with OCT)1	0	0	2	6	9	32	25	29	36	16
2: Significant (i.e., visible by color photography or ophthalmoscopy)	0	0	0	0	1	4	60	69	61	27
Treatment
Nil	71	100	36	100	28	100	5	6	140	63
PDT	0	0	0	0	0	0	7	8	7	3
Brachytherapy	0	0	0	0	0	0	68	78	68	31
Proton beam	0	0	0	0	0	0	5	6	5	2
Enucleation	0	0	0	0	0	0	2	2	2	1
Total	71	32	36	16	28	13	87	39	222	100

Tumors are categorized as “common nevus,” “low-risk nevus,” “high-risk nevus,” and “probable melanoma” according to whether the sum total of the scores for the 5 indicators of malignancy is 0, 1, 2 or >2. CF, count fingers; DD, disc diameters; HM, hand motions; NLP, no light perception; PDT, photodynamic therapy; SRF, subretinal fluid.

¹If ultrasonography is not available, tumor thickness is measured with OCT. If OCT is not possible, thickness is estimated to be >1 mm, 1–2 mm, or >2 mm if the tumor ophthalmoscopically appears flat, minimally thickened, or having a prominent dome or mushroom shape. Cystic intra-retinal edema and retinal pigment epithelial abnormality with cobblestone degeneration or hyper-autofluorescence are not significant if the retina is flat.