Table 3. Standard semen parameters, advanced sperm function tests, and reproductive outcomes evaluated in trials investigating antioxidant treatment in male infertility (n=69).
| Parameters evaluated | Number of studies | Percentage of studies evaluated | |
|---|---|---|---|
| Standard Semen parameters | 64 | 93 | |
| Sperm function tests | 65 | 94 | |
| Oxidative stress | 35 | 51 | |
| Sperm DNA damage | 16 | 23 | |
| Capacitation/acrosome reaction | 3 | 4 | |
| Zona binding | 2 | 3 | |
| Mitochondrial membrane integrity | 2 | 3 | |
| Annexin V binding | 2 | 3 | |
| Propidium iodide double staining | 2 | 3 | |
| HBA test | 1 | 1 | |
| HOS test | 1 | 1 | |
| MAR test | 1 | 1 | |
| Reproductive outcomes | 33 | 48 | |
| Pregnancy rate | 23 | 33 | |
| Fertilization rate | 4 | 6 | |
| Live birth rate | 3 | 4 | |
| Implantation rate | 1 | 1 | |
| Miscarriage rate | 1 | 1 | |
| Embryo quality | 1 | 1 | |
HBA: sperm-hyaluronic acid binding, HOS: hypo-osmotic swelling, MAR: mixed agglutination reaction.