Table 3. Association Between Duration of Prenatal Analgesic Opioid Exposure and ADHD Diagnosis and ADHD Symptoms in Children Aged 5 Years.
Length of exposure | No. | Events, No. | IR per 1000 person-years | Crude HR (95% CI) | Weighted HR (95% CI) |
---|---|---|---|---|---|
ADHD diagnosis sample | |||||
Exposed in ≤4 weeks | 1084 | 48 | 4.0 | 1 [Reference] | 1 [Reference] |
Exposed ≥5 weeks | 642 | 43 | 6.2 | 1.60 (1.06 to 2.41) | 1.60 (1.04 to 2.47) |
ADHD symptoms sample | |||||
Length of exposure | No. | Mean | SD | Crude β (95% CI) | Weighted β (95% CI) |
Exposed in ≤4 weeks | 423 | 1.41 | 0.40 | [Reference] | [Reference] |
Exposed ≥5 weeks | 244 | 1.40 | 0.40 | −0.01 (−0.18 to 0.15) | −0.05 (−0.25 to 0.15) |
Abbreviations: ADHD, attention-deficit/hyperactivity disorder; HR, hazard ratio; IR, incidence rate.