1. Percentage change in seizure frequency in Herzog 2012.

Seizure type	Progesterone		Placebo		P value
	n	Median (IQR) (%)	n	Median (IQR) (%)
All seizures	79	−19.9 (−49.4 to 7.4)	45	−12 (−43.0 to 8.5)	0.393
Most severe seizure type	79	−22.7 (−67.1 to 13.6)	45	−12 (−51.6 to 11.4)	0.483
Secondarily generalised motor seizures	33	−38.1 (−95.1 to 15.3)	17	−23.7 (−79.4 to 11.9)	0.797
Complex partial seizures	76	−15.4 (−46.2 to 0.0)	43	0 (−45.7 to 21.3)	0.147
Simple partial seizures	34	−25.2 (−84.9 to 26.0)	17	−25.7 (−93.5 to 3.16)	0.527

IQR: interquartile range