| 1.1 Seizure freedom |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.1.1 All seizures |
1 |
124 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.02 [0.21, 76.21] |
| 1.1.2 Most severe seizure type |
1 |
124 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.09 [0.61, 7.10] |
| 1.2 Responder rate (50% reduction in seizure frequency) |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 All seizures |
1 |
124 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.14 [0.56, 2.32] |
| 1.2.2 Most severe seizure type |
1 |
124 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.24 [0.67, 2.29] |
| 1.2.3 Secondarily generalised motor seizures |
1 |
50 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.34 [0.57, 3.13] |
| 1.2.4 Complex partial seizures |
1 |
119 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.27 [0.60, 2.68] |
| 1.2.5 Simple partial seizures |
1 |
51 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.50, 2.01] |
| 1.3 Seizure frequency |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.3.1 In the 3 months before the study |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.40 [‐4.39, 1.59] |
| 1.3.2 In the 3 months after the study |
1 |
36 |
Mean Difference (IV, Fixed, 95% CI) |
‐4.50 [‐6.55, ‐2.45] |
| 1.4 Number of withdrawals from the study |
2 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.4.1 Withdrawals for any reason |
2 |
168 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.56 [0.81, 3.00] |
| 1.4.2 Withdrawals due to adverse events |
2 |
168 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.91 [0.53, 16.17] |
| 1.5 Any adverse events reported |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 1.6 Adverse events reported in > 5% of participants |
1 |
|
Risk Ratio (M‐H, Fixed, 99% CI) |
Subtotals only |
| 1.6.1 Diarrhoea |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.53 [0.09, 3.07] |
| 1.6.2 Dyspepsia |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.53 [0.04, 6.66] |
| 1.6.3 Nausea |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.08 [0.00, 3.65] |
| 1.6.4 Vomiting |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.53 [0.04, 6.66] |
| 1.6.5 Fatigue |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
1.48 [0.42, 5.20] |
| 1.6.6 Nasopharyngitis |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.18 [0.00, 11.65] |
| 1.6.7 Dizziness |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.26 [0.05, 1.54] |
| 1.6.8 Headache |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
0.79 [0.08, 7.94] |
| 1.6.9 Depression |
1 |
130 |
Risk Ratio (M‐H, Fixed, 99% CI) |
2.12 [0.12, 36.26] |
