Table 3.
Simple and Multiple Linear Regression Analyses of Factors Associated with PCDAI
| Variable | Simple linear regression analysis | Multiple linear regression analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β±SE | 95% CI | Partial R2 | p-value | β±SE | 95% CI | Partial R2 | p-value | ||
| Sex (male vs female) | 0.268±3.639 | –7.226 to 7.762 | 0.000 | 0.942 | |||||
| Age at diagnosis, yr | –0.051±0.642 | –1.373 to 1.271 | 0.000 | 0.938 | |||||
| Upper GI tract involvement (yes vs no) | 2.375±3.174 | –4.162 to 8.912 | 0.022 | 0.461 | |||||
| B1 disease behavior (yes vs no) | –1.234±3.484 | –8.408 to 5.941 | 0.005 | 0.726 | |||||
| Perianal modifiers (yes vs no) | 5.750±2.996 | –0.421 to 11.921 | 0.128 | 0.066 | |||||
| Linear growth failure (yes vs no) | –3.016±4.448 | –12.178 to 6.145 | 0.018 | 0.504 | |||||
| WBC,/μL | –0.001±0.001 | –0.002 to 0.000 | 0.055 | 0.240 | |||||
| Hct, % | –0.014±0.027 | –0.069 to 0.042 | 0.010 | 0.617 | |||||
| Platelet count,/μL | –0.020±0.015 | –0.051 to 0.012 | 0.061 | 0.213 | |||||
| Albumin, g/dL | –4.712±2.676 | –10.224 to 0.799 | 0.110 | 0.090 | |||||
| ESR, mm/hr | 0.001±0.051 | –0.104 to 0.106 | 0.000 | 0.985 | |||||
| CRP, mg/dL | 0.212±0.460 | –0.735 to 1.159 | 0.008 | 0.649 | |||||
| IFX trough level, μg/mL | –0.113±0.328 | –0.791 to 0.565 | 0.005 | 0.734 | |||||
| ASCA IgA, units | 0.492±0.170 | 0.142 to 0.842 | 0.252 | 0.008* | |||||
| ASCA IgG, units | 0.377±0.090 | 0.192 to 0.562 | 0.414 | <0.001* | 0.377±0.090 | 0.192 to 0.562 | 0.414 | <0.001* | |
PCDAI, pediatric Crohn’s disease activity index; SE, standard error; CI, confidence interval; GI, gastrointestinal; WBC, white blood cell; Hct, hematocrit; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; IFX, infliximab; ASCA, anti-Saccharomyces cerevisiae antibody; IgA, immunoglobulin A; IgG, immunoglobulin G.
*p<0.05.