Table 1.
Characteristics of the transgender and matched reference cohorts*
| Participant | TF cohort | TM cohort | CM referents | CF referents |
|---|---|---|---|---|
| characteristics | (n = 624) | (n = 438) | (n = 4090) | (n = 4797) |
| Membership site | ||||
| KPNC | 359 (57.5) | 300 (68.5) | 2494 (61.0) | 3026 (63.1) |
| KPSC | 252 (40.4) | 135 (30.8) | 1536 (37.6) | 1725 (36.0) |
| KPGA | 13 (2.1) | 3 (0.7) | 60 (1.5) | 46 (1.0) |
| Race/ethnicity | ||||
| Non-Hispanic white | 348 (55.8) | 271 (61.9) | 2533 (61.9) | 2914 (60.7) |
| Non-Hispanic black | 47 (7.5) | 45 (10.3) | 338 (8.3) | 469 (9.8) |
| Hispanic | 119 (19.1) | 69 (15.8) | 653 (16.0) | 812 (16.9) |
| Asian/Pacific Islander | 70 (11.2) | 31 (7.1) | 412 (10.1) | 425 (8.9) |
| Other/Unknown | 40 (6.4) | 22 (5.0) | 154 (3.8) | 177 (3.7) |
| Age at index date, y | ||||
| 18–25 | 195 (31.3) | 185 (42.2) | 682 (16.7) | 987 (20.6) |
| 26–35 | 155 (24.8) | 148 (33.8) | 915 (22.4) | 1235 (25.7) |
| 36–45 | 122 (19.6) | 58 (13.2) | 903 (22.1) | 988 (20.6) |
| 46–55 | 81 (13.0) | 37 (8.4) | 870 (21.3) | 859 (17.9) |
| >55 | 71 (11.4) | 10 (2.3) | 720 (17.6) | 728 (15.2) |
| BMI at index date | ||||
| Normal weight/Underweight | 275 (44.1) | 161 (36.8) | 918 (22.4) | 1626 (33.9) |
| Obese | 165 (26.4) | 118 (26.9) | 1431 (35.0) | 1228 (25.6) |
| Overweight | 144 (23.1) | 142 (32.4) | 1414 (34.6) | 1603 (33.4) |
| Unknown | 40 (6.4) | 17 (3.9) | 327 (8.0) | 340 (7.1) |
| Alcohol use/abuse | ||||
| Yes | 70 (11.2) | 56 (12.8) | 595(14.5) | 566 (11.8) |
| No | 554 (88.8) | 382 (87.2) | 3495(85.5) | 4231 (88.2) |
| Lab test data available | ||||
| ALT | 618 (99.0) | 432 (98.6) | 4002 (97.8) | 4619 (96.3) |
| AST | 240 (38.5) | 150 (34.2) | 1469 (35.9) | 1952 (40.7) |
| ALT levels | ||||
| pre-GAHT | 24.0 (19.0) | 20.0 (15.0) | 28.0 (22.0) | 19.0 (15.0) |
| on-GAHT | 19.0 (14.0) | 22.0 (18.0) | 27.0 (20.0) | 19.0 (15.0) |
| AST levels | ||||
| pre-GAHT | 23.0 (12.0) | 22.0 (12.0) | 26.0 (18.0) | 21.0 (12.0) |
| on-GAHT | 21.0 (12.0) | 23.0 (11.5) | 25.0 (17.0) | 22.0 (13.0) |
*
Calculated as n (%) for membership site, race/ethnicity, age, lab test, BMI, alcohol use/abuse, and as median (interquartile range) for ALT and AST average level. Percentages may not sum to 100 due to rounding.ALT = alanine aminotransferase; AST = aspartate aminotransferase; BMI = body mass index; CF = cisgender females; CM = cisgender males; KPGA = Kaiser Permanente Georgia; KPNC = Kaiser Permanente Northern California; KPSC = Kaiser Permanente Southern California; TF = transfeminine; TM = transmasculine; GAHT = gender-affirming hormone treatment.