Table 2.
Heavy and light chain family and full sequence information for select characterized candidate antibodies
| ID | Mouse strain | Heavy V Gene | Heavy V Gene Identity % | VDJ Region |
|---|---|---|---|---|
| 15G11 | DivergimAb | IGHV1S137 | 98.64 | QVQLQQSGAELVRPGVSVKISCKGSGYTFTDYAMHWVKQSHAKSLEWIGVISTYYGDASYN QKFKGKATMTVDKSSSTAYMELARLTSEDSAIYYCARWANWGYYYAMDYWGQG TSVTVSS |
| 18F4 | DivergimAb | IGHV2-9-1 | 100 | QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYAISWVRQPPGKGLEWLGVIWTGGGTNYN SALKSRLSISKDNSKSQVFLKMNSLQTDDTARYYCARKDYYGSSRNAMDYWGQGTSVT VSS |
| 1E5 | DiversimAb | IGHV1-55 | 100 | QVQLQQPGAELVKPGASVKMSCKASGYTFTSYWITWVKQRPGQGLEWIGDIYPGSGST NYNEKFKSKATLTVDTSSSTAYMQLSSLTSEDSAVYYCARSTVVATDAMDYWGQGTSVT VSS |
| 1G3 | DiversimAb | IGHV2-9-1 | 100 | QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYAISWVRQPPGKGLEWLGVIWTGGGTNYNSALKS RLSISKDNSKSQVFLKMNSLQTDDTARYYCARFHYYGSSYGYFDYWGQGTTLTVSS |
| 21C3 | DivergimAb | IGHV2-9-1 | 100 | QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYAISWVRQPPGKGLEWLGVIWTGGGTNYNSALK RLSISKDNSKSQVFLKMNSLQTDDTARYYCARIYYYGSSYFDYWGQGTTLTVSS |
| 22D9 | DivergimAb | IGHV1-54 | 100 | QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGVINPGSGGTNYN EKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCARRHYYYGVDYWGQGTTLTVSS |
| 23D11 | DivergimAb | IGHV1S113 | 97.22 | EVQLQQSGPELVKPGASVKISCKTSGYTFTEYTMYWVKQSHGKSLEWIGGVNPNNGDTSYSQ KFKGKATLTVDKSSSTAYMELRSLTSEDSAVYYCARDGYDLYYGMDYWGQGTSVTVSS |
| 26E2 | DivergimAb | IGHV14-4 | 100 | EVQLQQSGAELVRPGASVKLSCTASGFNIKDDYMHWVKQRPEQGLEWIGWIDPENGDTEYA SKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCTKGYYGSSYDYFDYWGQGTTLTVSS |
| 29F7 | DivergimAb | IGHV1-82 | 100 | QVQLQQSGPELVKPGASVKISCKASGYAFSSSWMNWVKQRPGKGLEWIGRIYPGDGDTNYN GKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCARDDYDEGDYWGQGTTLTVSS |
| 3B3 | DiversimAb | IGHV5-9-1 | 100 | DVKLVESGEGLVKPGGSLKLSCAASGFTFSSYAMSWVRQTPEKRLEWVAYISSGGDYIYYAD TVKGRFTISRDNARNTLYLQMSSLKSEDTAMYYCTRVARLYDGYFDYWGQGTTLTVSS |
| 3F2 | DiversimAb | IGHV14-4 | 97.95 | EVQLQQSGAELVRPGASVKLSCTASGFNIKDDYMHWVKQRPEQGLEWIGWIDPENGDTEYAS KFQGKATITVDISSNTAYLQLNSLTSEDTAVYYCSTLIYYYGSSNDYWGQGTTLTVSS |
| D59047-11955 | DivergimAb | IGHV2-9-1 | 100 | QVQLKESGPGLVAPSQSLSITCTVSGFSLTSYAISWVRQPPGKGLEWLGVIWTGGGTNYNSAL KSRLSISKDNSKSQVFLKMNSLQTDDTARYYCARIYYYGSSYFDYWGQGTTLTVSS |
| D70678-12637-S1 | Alloy | IGHV3-21 | 96.94 | EVQLVESGGGLVKPGGSLRLSCATSGFTFSHYSMNWVRQAPGKGLEWVSSISSSSSNIYYADS VKGRFTVSRDNAKNSLYLQMNSLRAEDTAVYYCARRGSSWSFDYWGQGTLVTVSS |
| D70678-12799-S1 | Alloy | IGHV1-2 | 97.95 | QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGWINPNSGGTN YAQKFQGRVTMTRDTSISTAYMELSRLRSDDTALYYCARLDYWSQGTLVTVSS |
| D70678-13531-S1 | Alloy | IGHV4-59 | 94.9 | QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWTWIRQSPGKGLEWIGYIYYSGSTYTNPSLKS RVTFSVDTSENQFSLKLNSVTAADTAIYFCARDNMDVWGKGTTVTVSS |
| D70678-13576-S1 | Alloy | IGHV4-59 | 94.58 | QVQLQESGPGLVKPSETLSLTCTVSGGSISNYYWTWIRQPPGKGLEWIGYIYYSGSTYTNPSLK SRVTISVDTSENQFSLKLNSVTAADTAIYYCARDNMDVWGKGTTVTVSS |
| D70678-14004-S2 | Alloy | IGHV1-18 | 97.64 | QVQLVQSGAEVKKPGASVKVSCKASGYTFSSYGIIWVRQAPGQGLEWMGWISAYNGNTNYA QKLQGRVTMTTDTSTSTAYMELRTLRSDDTAVYYCAREITLNWNYAGWFDPWGQGTLVTVSS |
| D70678-14027-S2 | Alloy | IGHV3-15 | 97.33 | EVQLVESGGGLVKPGGSLRLSCAASGFTFSYAWMTWVRQAPGKGLEWVGRIKTKSDGGTT DYASPVKGKFTISRDDSKNTLYLQMNSLQTEDTAVYYCTTHSSPDYWGQGTLVTVSS |
| D70678-2155-S1 | Alloy | IGHV3-15 | 94.06 | QVQLVESGGDLVKPGGSLRLSCAASGFTFSNAWMTWVRQAPGKELEWVGRIKTKSDGGTIE YGVSVKGRFTISRDDSKNTLFLQMNSLTTEDTAVYYCTTHSSPDYWGQGTLVTVSS |
| D70678-2743-S1 | Alloy | IGHV4-59 | 95.25 | QVQLQESGPGLVKPSETLSLTCTVSGGSISSYYWTWIRQPPGKGLEWIGYIYSSGSTYTNPSLK SRVTISVDTSENQFSLKLNSVTAADTAVYYCARDNMDVWGKGTTVTVSS |
| D70678-5521-S2 | Alloy | IGHV3-15 | 97 | EVQLVESGGGLVKPGGSLRLSCAASGFTFNYAWMTWVRQAPGKGLDWVGRIKTKTDSGTTD YAAPVKGRFTISRDDSKNTLYLQMNNLKTEDTAVYYCTTHSTPDYWGQGTLVTVSS |
| ID | Mouse strain | Light V Gene | Light V Gene Identity % | VJ Region |
| 15G11 | DivergimAb | IGLV1 | 99.66 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPAR FSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVL |
| 18F4 | DivergimAb | IGLV1 | 100 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPAR FSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVL |
| 1E5 | DiversimAb | IGKV2-109 | 100 | DIVMTQAAFSNPVTLGTSASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGV PDRFSSSGSGTDFTLRISRVEAEDVGVYYCAQNLELPWTFGGGTKLEIK |
| 1G3 | DiversimAb | IGLV1 | 99.32 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPA RFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVL |
| 21C3 | DivergimAb | IGLV1 | 99.66 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPA RFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNQFIFGSGTKVTVL |
| 22D9 | DivergimAb | IGKV14-111 | 100 | DIKMTQSPSSMYASLGERVTITCKASQDINSYLSWFQQKPGKSPKTLIYRANRLVDGVPSR FSGSGSGQDYSLTISSLEYEDMGIYYCLQYDELYTFGGGTKLEIK |
| 23D11 | DivergimAb | IGKV6-15 | 99.3 | DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNVAWYQQKPGQSPKALIYSASYRYSGVPDR FTGSGSGTDFTLTISNVQSVDLAEYFCHQYNSYPWTFGGGTKLEIR |
| 26E2 | DivergimAb | IGKV19-93 | 99.65 | DIQMTQSPSSLSASLGGKVTITCKASQDINKYIAWYQHKPGKGPRLLIHYTSTLQPGIPSRFS GSGSGRDYSFSISNLEPEDIATYYCLQYDNLWTFGGGTKLEIK |
| 29F7 | DivergimAb | IGKV6-15 | 100 | DIVMTQSQKFMSTSVGDRVSVTCKASQNVGTNVAWYQQKPGQSPKALIYSASYRYSGVPDR FTGSGSGTDFTLTISNVQSEDLAEYFCQQYNSYPLYTFGGGTKLEIK |
| 3B3 | DiversimAb | IGKV3-10 | 100 | NIVLTQSPASLAVSLGQRATISCRASESVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVP ARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPYTFGGGTKLEIK |
| 3F2 | DiversimAb | IGLV1 | 100 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPA RFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVL |
| D59047-11955 | DivergimAb | IGLV1 | 99.66 | QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPA RFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNQFIFGSGTKVTVL |
| D70678-12637-S1 | Alloy | IGKV3-20 | 97.19 | EIVLTQSPATLSLSPGERAILSCRASQSISSTYLAWNQQKPGQAPRLLIYGASSRATGIPDRFSG SGSGTDFTLTISRLEPEDFAVYYCQQYGSSWTFGQGTKVEIK |
| D70678-12799-S1 | Alloy | IGKV2-24 | 94.67 | DIVMTQTPLSLPVTLGQPASISCRSSQSLVHSDGNTYLSWLQQRPGQPPRLLIYKISNRFSGVP DRFSGSGAGTDFTLKISRVEAEDVGVYYCMQETQFTWTFGQGTKVEIK |
| D70678-13531-S1 | Alloy | IGKV2-30 | 97.99 | DVVMTQTPLSLPVTLGQPASISCRCSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSIRDSGVP DRFSGSGSGTDFTLKISRVEAEDVGIYYCMQGTHRPITFGRGTRLEIK |
| D70678-13576-S1 | Alloy | IGKV4-1 | 94.7 | DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGV PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPYTFGQGTKLEIK |
| D70678-14004-S2 | Alloy | IGKV3-15 | 96.52 | EIVMTQSPATLSVSPGERATLSCRASQSIRNNLAWYQQKPGQAPRLLIYGAISRATGVPARFSG SGSGTEFTLTISSLQSEDFAVYHCQQYNNWLPYTFGQGTKLEIK |
| D70678-14027-S2 | Alloy | IGKV1-33;IGKV1D-33 | 99.3 | DIQMTQSPSSLSASVGDRVTITCQASQDIRNYLNWYHQKPGKAPKLLIYDASNLETGVPSRFS GSGSGTDFTFTISSLQPEDIATYYCQQYDNLPYTFGQGTKLEIK |
| D70678-2155-S1 | Alloy | IGKV1-33;IGKV1D-33 | 96.86 | DIQMTQSPSSLSASVGDRVTITCQASQDIRNYLNWYQQKPGKAPKLLIYDASTLETGVPSRFS GSGSGTDFTFTISSLQPEDIATYYCHQYGNLPLSFGGGTKVEIK |
| D70678-2743-S1 | Alloy | IGKV2-30 | 95.65 | DVVMTQTPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNWFQQRPGQSPRRLIYKVSNRDSG VPDRFSGSGSGTDFTLKISRVEAEDVGIYYCMQGTHWPIIFGRGTRLEIK |
| D70678-5521-S2 | Alloy | IGKV1-33;IGKV1D-33 | 98.24 | DIQMTQSPSSLSASVGDRVTITCQASQDINNHLNWYQQKPGKAPNLLIYDASNLETGVPSR FSGSGSGTDFTFTISSLQPEDFATYYCQQYDNLPYTFGQGTKLEIK |