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SHP2 reduces IL-6-induced STAT3 phosphorylation. a MEF wt, MEF SHP2 ΔEx3, and MEF SHP2 ΔEx3 + SHP2 cells were stimulated with 10 ng/ml Hy-IL-6 for 30 min. b MEF wt cells were stimulated with 10 ng/ml Hy-IL-6 for the indicated times. STAT3-Y705, SHP2-Y542 phosphorylation and SHP2, STAT3, SOCS3, Tubulin, and HSC70 expression were evaluated by Western Blotting. Representative results of n = 3 experiments are shown
