Fig. 7.

Mutation of SHP2 reduces information transfer and robustness in JAK/STAT signalling. Wt SHP2 contributes to the robustness of STAT3 activation and thus to the independence of the strength of STAT3 activation from varying STAT3 expression, both in unstimulated cells (pre-stimulation) and in cells stimulated with IL-6 for short periods of time (early IL-6-signalling). However, SHP2 does not affect robustness of late IL-6-induced STAT3 activation. Additionally, SHP2 increases the amount of information transferred within early IL-6-induced JAK/STAT signalling. In contrast to SHP2, SOCS3 ensures robustness of late IL-6-induced JAK/STAT signalling.