Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 8;46(5):232. doi: 10.3892/or.2021.8183

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Zeng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 1. — Mechanisms of NK cells exerting cytotoxicity. NK cells induce target cell apoptosis by releasing cytoplasmic particles containing granzymes and perforin (yellow arrow). NK cells play a role through the tumor necrosis factor family (red arrow). NK cells secrete various effector molecules interacting with other immune cells (blue arrow). NK cells eliminate target cells through the ADCC (green arrow). NK, natural killer; ADCC, antibody-dependent cell-mediated cytotoxicity; DC, dendritic cell; FASL, factor-associated suicide ligand; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; TRAIL, TNF related apoptosis inducing ligand; Ab, antibody; Ag, antigen.