Bioactive mometasone furoate can be released from TEMPS for 4 weeks in vitro. (A) Size distribution and (inset) representative scanning electron micrograph, scale bar = 10 μm, of drug-loaded MSs showing a smooth, spherical morphology with mean diameter of 7.8 μm. (B) Cumulative release of mometasone furoate from MSs (n = 3) and (C) TEMPS, MSs embedded in thermogel (n = 5). Error bars represent mean ± cumulative S.D. (D) Drug released from TEMPS after 28 days of aqueous incubation at 37 °C displays activity (EC50 = 0.33 pM) similar to a control, drug prepared the day of the assay (EC50 = 0.31 pM).