Table 1.
Clinical characteristics of 423 healthcare workers with COVID-19, and bivariate analysis comparing cases caused by the Gamma variant with cases caused by strains that are not variants of concern (non-VoC) (Hospital das Clínicas, São Paulo, Brazil. January 22 - May 15, 2021).
| Gamma variant (N = 313) | Non-VoC (N = 110) | pa | |
|---|---|---|---|
| N (%) or median (25th–75th percentile) | |||
| Age (years) | 37 (29–49) | 39 (31–46) | 0.452 |
| Age strata (years) | 0.890 | ||
| 16–40 | 189 (60%) | 67 (61%) | |
| 41–60 | 106 (34%) | 38 (35%) | |
| > 60 | 18 (6%) | 5 (5%) | |
| Female | 220 (70%) | 76 (69%) | 0.814 |
| Pre-existing conditions | |||
| Hypertension | 35 (11) | 12 (11) | 0.938 |
| Hyperlipidemia | 17 (5) | 7 (6) | 0.716 |
| Chronic pulmonary disease | 16 (5) | 2 (2) | 0.176 |
| Type 2 diabetes mellitus | 15 (5) | 4 (4) | 0.791 |
| Heart disease | 14 (5) | 6 (6) | 0.676 |
| Obesity | 7 (2) | 1 (1) | 0.686 |
| Chronic kidney disease | 3 (1) | 0 | 0.571 |
| Immunosuppressive drug use | 2 (1) | 2 (2) | 0.278 |
| Cancer | 2 (1) | 1 (1) | 1.000 |
| Solid-organ transplantation | 1 (0) | 0 | 1.000 |
| Pregnancy | 4/220 (2) | 1/76 (1) | 0.932 |
| Work category | 0.628 | ||
| Nursing technician | 79 (25) | 25 (23) | |
| Administrative staff | 66 (21) | 23 (21) | |
| Physician | 58 (18) | 16 (14) | |
| Auxiliary health teamb | 43 (14) | 20 (18) | |
| Nurse | 27 (9) | 11 (10) | |
| Multidisciplinary health teamc | 18 (6) | 10 (9) | |
| Others | 22 (7) | 5 (5) | |
| Vaccination status and type of vaccine | < 0.001 | ||
| Unvaccinated | 44 (14) | 22 (20) | |
| Partially immunized d | 99 (32) | 83 (75) | |
| CoronaVac | 71 (72) | 81 (98) | |
| ChAdOx1 | 19 (19) | 1 (1) | |
| Unknown | 9 (9) | 1 (1) | |
| Fully immunized e | 170 (54) | 5 (5) | |
| CoronaVac | 168 (98) | 5 (100) | |
| ChAdOx1 | 1 (1) | 0 | |
| BNT162b2 | 1 (1) | 0 | |
| Symptoms on diagnosis | |||
| Coryza | 236 (75) | 71 (65) | 0.028 |
| Headache | 230 (74) | 76 (69) | 0.376 |
| Cough | 227 (73) | 74 (67) | 0.296 |
| Sore throat | 170 (54) | 52 (47) | 0.203 |
| Myalgia | 159 (51) | 43 (39) | 0.034 |
| Asthenia | 137 (44) | 43 (39) | 0.393 |
| Fever | 94 (30) | 43 (39) | 0.81 |
| Hyposmia/anosmia f | 78 (25) | 51 (46) | < 0.001 |
| Dysgeusia f | 66 (21) | 42 (38) | < 0.001 |
| Gastrointestinal tract symptomsg | 63 (20) | 33 (30) | 0.033 |
| Dyspnea | 31 (10) | 8 (7) | 0.412 |
| Duration of symptoms (days) | 3 (2 - 4) | 3 (2–4) | 0.823 |
| COVID-19 diagnosed previously | 7 (2) | 10 (9) | 0.002 |
| Previous positive RT- PCR | 3 (43) | 0 | |
| Previous positive serology | 4 (57) | 10 (100) | |
| Hospitalization | 5 (2) | 3 (2) | 0.434 |
| Oxygen supplementation | 4 (1) | 3 (3) | 0.383 |
| Admission to intensive care unit | 3 (1) | 2 (2) | 0.608 |
| Invasive mechanical ventilation | 3 (1) | 0 | 0.571 |
| Vasoactive drug support | 2 (1) | 0 | 1.000 |
| Thromboembolic event | 2 (1) | 1 (1) | 0.772 |
| Death | 3 (1) | 0 | 0.571 |
Calculated by Chi-square test or Mann Whitney U test.
Included workers of pharmacy, laboratory, radiology, security, and medical students.
Included physiotherapist, dentist, psychologist, nutritionist, and social services.
Recipients of at least one dose of a COVID-19 vaccine and recipients of 2nd dose in the last 13 days.
Recipients of two doses of a COVID-19 vaccine at least 14 days after the second dose.
The simultaneous dysfunction of taste and smell was present in 93 (30%) Gamma variant cases and 58 (53%) non-VoC cases.
Abdominal pain, diarrhea, nausea, or vomiting.