Fig. 1.

IGF-2 reduced cortical and hippocampal delta power in Ube3a^mat−/pat+ rats. a Baseline cortical and b hippocampal power pre-injection trended higher in Ube3a^mat−/pat+ (mat-/pat +) rats compared to wildtype (Ube3a^mat+/pat+; mat + /pat +) rats. c Following injection of IGF-2, cortical and d hippocampal power were unaltered in wildtype rats. e Cortical and f hippocampal power were unchanged by IGF-2 in mat-/pat + rats. g Cortical power at 1 and 2 Hz (“delta power”) was lower in mat-/pat + rats following treatment with 10 or 30 µg/kg IGF-2 compared to vehicle. h Across both genotypes, hippocampal delta power (at 1 and 2 Hz) was also reduced by 10 and 30 µg/kg IGF-2. Data are expressed as mean ± S.E.M. n = 3–4 rats/genotype. g, h *p < 0.05, Tukey’s multiple comparisons following repeated measures ANOVA