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. 2021 Sep 15;12:59. doi: 10.1186/s13229-021-00467-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — IGF-2 did not rescue or improve gait deficits in Ube3a^mat−/pat+ mice. a Compared to wildtype littermates (Ube3a^mat+/pat+; mat+/pat+), Ube3a^mat−/pat+ (mat-/pat+) mice exhibited wider stances while treadmill walking, which were reduced by IGF-2 treatment in the forelimbs but unaffected by IGF-2 in the hindlimbs. b Stride lengths were increased in mat-/pat+ mice and were further increased by IGF-2 while c the reduced stride frequency of mat-/pat+ mice was further decreased in forelimbs by IGF-2. d IGF-2 had no effect on the elevated forelimb propulsion time of mat-/pat+ mice and led to further elevation of the increased hindlimb propulsion time. e Swing time was elevated in mat-/pat+ mice, regardless of IGF-2 treatment and f brake time was normal in mat-/pat+ mice and unchanged by IGF-2. Data are expressed as mean ± S.E.M. n = 17–24 mice/group. a, c *Genotype, p < 0.05, main effect of genotype via two-way ANOVA (per limb set); *Treatment, p < 0.05, main effect of treatment via two-way ANOVA (per limb set). a-f *p < 0.05, Tukey’s multiple comparisons test following two-way ANOVA (per limb set)