Fig. 1.

Reduced frequencies of Tregs in patients with NMOSD. A The proportions and counts per microliter of circulating CD3⁺CD19⁻ T cells, CD3⁺CD4⁺ cells, CD3⁺CD8⁺ cells out of CD3⁺CD19⁻ T cells in HC groups (n = 21) and NMOSD (n = 25). The ratio of CD3⁺CD4⁺ cells to CD3⁺CD8⁺ cells is shown in the box-plot diagram with median and interquartile range. *p < 0.05, **p < 0.01. B Percentages of Tregs (CD3⁺CD4⁺CD25⁺CD127^low+ T cells), effector Tregs (CD45RO⁺CD3⁺CD4⁺CD25⁺CD127^low+ T cells), and naïve Tregs (CD45RA⁺CD3⁺CD4⁺CD25⁺CD127^low+ T cells) among the total CD3⁺CD4⁺ cells population from HC (n = 21) and NMOSD (n = 25) groups. *p < 0.05, **p < 0.01. C The percentage of Tregs and naïve Tregs in a receiver operating characteristic model with an area under the curve value of 0.718 and 0.770 respectively