Interfaces and interactions of sybodies with the RBD.A, Sb16–RBD; (B) Sb45–RBD; (C) Sb14–RBD; and (D) Sb68–RBD. (Individual contacting residues are listed in Table S1). CDR1, CDR2, and CDR3 are painted pink, orange, and red, respectively. Additional non-CDR-contacting residues are colored lime. On the RBD surface, the epitopic residues that contact the sybodies are colored according to the sybody CDR. CDR1, complementarity-determining region 1; CDR2, complementarity-determining region 2; CDR3, complementarity-determining region 3; RBD, receptor-binding domain.