Figure 4 .

Higher activity in light-phase in a wheel running test of female mice. (A) Ehd1 mutant female mice showed significantly higher rate of activity in light-phase per total activity. The test was performed for 18 weeks. Data shown are the mean ± standard error of the mean (SEM). The Kruskal–Wallis test was used for comparisons. n = 15 for each group. The post-hoc test was performed by Dunn’s multiple comparison test. WT versus Ehd1 mutant; P = 0.0025. WT versus Macf1 mutant; P = 0.40. Effect size, WT versus Ehd1 mutant; r = 0.59, WT versus Macf1 mutant; r = 0.23. (B) Representative actogram showing daily activity of each female mouse. The Ehd1 mutant mouse exhibited high activities in light-phase. Each row means the data of one day. The X-axis indicates local time. Y-axis of each row shows the wheel running activity per 10 min.