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. 2021 Sep 16;434(4):167249. doi: 10.1016/j.jmb.2021.167249

Figure 4.

Figure 4

Molecular mechanism of PANoptosis activation during IAV infection. The sensing of IAV Z-RNA by ZBP1 allows the activation of proteins involved in pyroptosis, apoptosis, and necroptosis to form the ZBP1-PANoptosome and mediate PANoptosis. Caspase-6 promotes the interaction between ZBP1 and RIPK3 in the ZBP1-PANoptosome. RIPK3 interacts with RIPK1, which can associate with FADD and caspase-8. Caspase-8 can also be associated with ASC, a core component of the inflammasome, recruiting NLRP3 and caspase-1. The executioners GSDMD, caspase-3 and -7, and MLKL are all activated in response to PANoptosome formation to drive PANoptosis. Created with BioRender.com.