Table 2.
Results of the evaluation of osteoclastogenesis
| Average osteoclast density (#/mm2) by position in femoral head (SD) | ||||||
|---|---|---|---|---|---|---|
| Subchondral bone | ||||||
| 1 | 2 | 3 | 4 | Total | P value | |
| CD | 13.9 (5.9) | 14.0 (4.4) | 10.2 (1.9) | 10.4 (7.2) | 12.1 (5.2) | 0.361 |
| HG | 16.4 (9.5) | 10.0 (5.5) | 11.7 (3.0) | 9.2 (7.7) | 11.8 (7.0) | 0.298 |
| MSC | 15.0 (6.4) | 14.8 (7.0) | 16.2 (12.4) | 9.1 (2.7) | 13.8 (7.9) | 0.816 |
| PGK-PDGF-BB-MSC | 13.7 (3.8) | 14.2 (6.6) | 16.5 (7.7) | 12.9 (7.3) | 14.3 (6.2) | 1.0 |
| Surrounding tunnel | |||||
|---|---|---|---|---|---|
| 5 | 6 | 7 | Total | P value | |
| CD | 10.7 (4.1) | 5.6 (4.8) | 13.4 (6.0) | 9.8 (5.8) | < 0.05 |
| HG | 9.9 (12.5) | 4.9 (4.8) | 4.0 (3.0) | 6.3 (7.9) | < 0.001 |
| MSC | 10.6 (4.5) | 6.9 (4.1) | 7.8 (5.3) | 8.4 (4.7) | < 0.01 |
| PGK-PDGF-BB-MSC | 17.5 (8.2) | 13.7 (8.6) | 17.8 (14.6) | 16.4 (10.4) | 1.0 |
The average osteoclast density for each position in the femoral head as described in Fig. 1 was calculated for each treatment group. The average osteoclast density for each region in the femoral head was calculated for each treatment group. A mixed effects model, where treatment group and femoral head position served as fixed effects, was used to perform the statistical analysis. The P values shown correspond to comparisons with the PGK-PDGF-BB-MSC treatment group. Comparisons between all other treatment groups did not reach statistical significance. SD standard deviation, CD core decompression, HG hydrogel, MSC mesenchymal stromal cell, PGK-PDGF-BB-MSC genetically modified phosphoglycerate kinase promoter platelet-derived growth factor-BB over-expressing MSC