Fig. 2.

Platelet expression of CD63 in patients receiving extracorporeal membrane oxygenation (ECMO) compared to controls. CD63 expression was analyzed by flow cytometry on resting (baseline), thrombin receptor activating peptide (TRAP)-stimulated and adenosine diphosphate (ADP)-stimulated platelets. Blood was sampled from ECMO patients (ECMO) on day 1, day 3 and after ECMO explantation (Post). CD63 expression on platelets was compared to healthy controls (Healthy) and patients with coronary artery disease (CAD). a, Baseline CD63 expression was significantly elevated on platelets from ECMO patients compared to controls. b, CD63 expression in response to TRAP was lower in ECMO patients compared to healthy controls. c, CD63 expression in response to ADP stimulation was similar in ECMO patients and controls. The number of ECMO patients remaining at each time point and the number of control patients are indicated below. Data are presented as mean ± standard error of the mean. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001