Table 1.
Clinicopathological features stratified by QMSP
| Valiables | All (n = 38) | Molecular surgical margin analysis | |||
|---|---|---|---|---|---|
| Negative (n = 21) | Positive (n = 17) | p value | |||
| Age, years | Median (range) | 66 (36–86) | 64 (36–86 | 72 (49–82) | 0.735 |
| Sex, n (%) | Female | 13 (34.2) | 7 (33.3) | 6 (35.3) | 1 |
| Male | 25 (65.8) | 14 (66.7) | 11 (64.7) | ||
| Tumor size, cm | Median (range) | 2.3 (0.9–4.3) | 2.5 (0.9–3.5) | 2.1 (1.0–4.3) | 0.401 |
| Initial resectability, n (%) | Resectable | 16 | 6 | 10 | 0.133 |
| Borderline resectable | 15 | 11 | 4 | ||
| Unresectable | 7 | 4 | 3 | ||
| NAT, n (%) | Yes | 24 (63.2) | 17 (81.0) | 7 (41.2) | 0.019 |
| No | 14 (36.8) | 4 (19.0) | 10 (58.8) | ||
| Radiation, n (%) | Yes | 3 (7.9) | 3 (14.3) | 0 (0) | 0.238 |
| No | 35 (92.1) | 18 (85.7) | 17 (100) | ||
| CA19-9, U/ml | Median (range) | 51.5 (1–5790 | 51 (1–5790 | 53 (1–1020) | 0.871 |
| DUPAN-2, U/ml | Median (range) | 61.5 (25–1000) | 47 (25–590) | 120 (25–1000) | 0.121 |
| Pathological surgical margin, n (%) | Positive | 11 (28.9) | 6 (28.6) | 5 (29.4) | 1 |
| Negative | 27 (71.1) | 15 (71.4) | 12 (70.6) | ||
| Pathological surgical margin, μm | Median (range) | 829 (0–4000) | 1081 (0–4000) | 372 (0–2648) | 0.521 |
| CY, n (%) | Positive | 3 (7.9) | 1 (4.8) | 2 (11.8) | 0.577 |
| Negative | 35 (92.1) | 20 (95.2) | 15 (88.2) | ||
| n, n (%) | Positive | 6 (15.8) | 5 (23.8) | 1 (5.9) | 0.197 |
| Negative | 32 (84.2) | 16 (76.2) | 16 (94.1) | ||
| ly, n (%) | Positive | 23 (60.5) | 12 (57.1) | 11 (64.7) | 0.744 |
| Negative | 15 (39.5) | 9 (42.9) | 6 (35.3) | ||
| v, n (%) | Positive | 16 (42.1) | 7 (33.3) | 9 (52.9) | 0.324 |
| Negative | 22 (57.9) | 14 (66.7) | 8 (47.1) | ||
| s, n (%) | Positive | 29 (76.3) | 16 (76.2) | 13 (76.5) | 1 |
| Negative | 9 (23.7) | 5 (23.8) | 4 (23.5) | ||
| rp, n (%) | Positive | 29 (76.3) | 15 (71.4) | 14 (82.4) | 0.476 |
| Negative | 9 (23.7) | 6 (28.6) | 3 (17.6) | ||
| ch, n (%) | Positive | 12 (31.6) | 6 (28.6) | 6 (25.3) | 0.734 |
| Negative | 26 (68.4) | 15 (71.4) | 11 (64.7) | ||
| du, n (%) | Positive | 15 (39.5) | 7 (33.3) | 8 (47.1) | 0.509 |
| Negative | 23 (60.5) | 14 (66.7) | 9 (52.9) | ||
| pv, n (%) | Positive | 12 (31.6) | 7 (33.3) | 5 (29.4) | 1 |
| Negative | 26 (68.4) | 14 (66.7) | 12 (70.6) | ||
Bold indicates P < 0.05
NAT; neoadjuvant chemotherapy, CY; Peritoneal washing cytology, n; Lymph node metastasis, ly; Lymphatic invasion, v; Venous invasion, s; Serosal side of the anterior pancreatic invasion, rp; Retropancreatic tissue invasion, ch; Bile duct invasion, du; Duodenal invasion, pv; Portal vein system invasion