Figure 2.

Mouse PGCs development and metabolo-epigenetic remodeling. Schematic representation of early embryonic development of PGCs in mouse, equivalent in vitro cell culture modeling, and main epigenetic remodeling events. mESCs and mouse PGCs (mPGCLCs) are both metabolically bivalent; however, distinct metabolic signatures are observed, where mESCs promote more glycolysis and mPGCLCs more OXPHOS. On the contrary, the epiblast-like cells intermediate (mEpiLCs) relies exclusively on glycolysis.