Figure 2 .

The study design of RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). In 10 study centers, the RHINESSA study has investigated the G3 offspring (N = 10 133/1607, questionnaire/clinical) of the G2 participants of the ECRHS and RHINE studies. ECRHS and RHINE have followed G2 participants over 20 years of childbearing years. In one study center, the Bergen RHINESSA study centre, also G1 and G4 has been investigated clinically, as well as the G2 other parent that was not included in the ECRHS/RHINE studies. Study participants of all generations have provided information about themselves, their parents, and potential offspring.