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. 2021 Aug 17;28(11):3856–3865. doi: 10.1111/ene.15045

TABLE 3.

Comparisons of brain pathology findings based on SARS‐CoV‐2 proteins in COVID‐19 patients

Brain pathology findings SARS‐CoV−2 proteins p value
Yes No
Edema Yes 21/38 (55.3%) 17/38 (44.7%) <0.001
No 21/88 (23.9%) 67/88 (76.1%)
Hypoxic‐ischemic lesions Yes 20/83 (24.1%) 63/83 (75.9%) 0.705
No 19/71 (26.8%) 52/71 (73.2%)
Hemorrhagic lesions Yes 1/14 (7.1%) 13/14 (92.9%) 0.241
No 28/140 (20.0%) 112/140 (80.0%)
Microgliosis Yes 17/100 (17.0%) 83/100 (83.0%) 0.429
No 12/54 (22.2%) 42/54 (77.8%)
Astrogliosis Yes 17/107 (15.9%) 90/107 (84.1%) 0.159
No 12/47 (25.5%) 35/47 (74.5%)
Inflammatory infiltrates Yes 17/108 (15.7%) 91/108 (84.3%) 0.133
No 12/46 (26.1%) 34/46 (73.9%)

Data are reported as number of patients (percent). p values were obtained using the Pearson χ2 test. Significant p values are bolded.