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. 2021 Sep 2;11:702258. doi: 10.3389/fonc.2021.702258

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Copyright © 2021 Cervena, Novosadova, Pardini, Naccarati, Opattova, Horak, Vodenkova, Buchler, Skrobanek, Levy, Vodicka and Vymetalkova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression analysis of miR-122-5p and miR-142-5p in EVs. (A, B) Expression levels of miR-122-5p and miR-142-5p were significantly lower in plasma EVs of RC patients compared to EVs of cancer-free individuals (for all p <0.001). (C, D) A year from the diagnosis (2^nd sampling, T1), a significant difference was observed between patients that do not respond a year after diagnosis and cancer-free individuals for miR-122-5p (4.9-fold change, p=0.007). This trend was not observed for miR-142-5p. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.