TABLE 4.

Multivariable analyses

	Insulin sensitivity by ISI		Insulin secretion by AUC-Ins30/AUC-Glu30		Disposition index by DI30		Insulin clearance by AUC-Cpep/AUC-ins
	β	P-value	β	P-value	β	P-value	β	P-value
Female	.18	<.01	−.12	.11	.087	.09	.13	<.01
African American	−.63	.17	.21	<.01	.16	<.01	−.31	<.01
Age	−.18	<.01	−.028	.58	−.26	<.01	−.079	.10
BMI	−.52	<.01	.32	<.01	−.29	<.01	−.33	<.01
Physical activity	.12	.01	−.12	.02	.013	.80	.089	.06

Abbreviations: AUC-Ins₃₀/AUC-Glu₃₀, insulin secretion; AUC-Cpep/AUC-Ins, insulin clearance; BMI, body mass index; DI₃₀, disposition index; ISI, insulin sensitivity index; β, standardized beta coefficient. Each column represents a multiple regression analysis, wherein the insulin homeostasis trait was the dependent variable, and sex, ethnicity, age, BMI and physical activity were the independent variables.